Article

Early Signs of Neuroinflammation in the Postnatal Wobbler Mice Model of Amyotrophic Lateral Sclerosis

2022-06-13

Abstract excerpt

The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomatic animals (3-5 months old) show vacuolar motoneuron degeneration, inflammation and gliosis accompanied by motor impairment. However, data are not conclusive concerning pathological changes appearing early after birth. To answer this question, we used postnatal day (PND) 6 genotyped Wobbler pups...

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Literature Corpus work: acc43d94-114c-5370-a4d6-da7208e534a0
DOI: 10.21203/rs.3.rs-1746673/v1

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