The wobbler mouse, an ALS animal model.

doi:10.1007/s00438-013-0741-0

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Article

The wobbler mouse, an ALS animal model.

Molecular genetics and genomics : MGG - 1 Jun 2013

Moser Jakob Maximilian, Bigini Paolo, Schmitt-John Thomas

Abstract excerpt

This review article is focused on the research progress made utilizing the wobbler mouse as animal model for human motor neuron diseases, especially the amyotrophic lateral sclerosis (ALS). The wobbler mouse develops progressive degeneration of upper and lower motor neurons and shows striking similarities to ALS. The cellular effects of the wobbler mutation, cellular transport defects, neurofilament aggregation,...

Topics

Amino Acid Sequence
Amyotrophic Lateral Sclerosis
Animals
Anti-Inflammatory Agents
Antioxidants
Disease Models, Animal
Humans
Male
Mice
Molecular Sequence Data
Motor Neuron Disease
Mutation
Spermatogenesis
Vesicular Transport Proteins

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Identifiers

PMID: 23539154
DOI: 10.1007/s00438-013-0741-0
PMCID: PMC3664746

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