Article
The wobbler mouse: a neurodegeneration jigsaw puzzle.
Molecular neurobiology - 1 Aug 2003
Boillée Séverine, Peschanski Marc, Junier Marie-Pierre
Abstract excerpt
Various mutations in humans and animals lead to the selective and progressive degeneration of motoneurons, resulting in muscular weakness, subsequent paralysis, and death (1-3). Amyotrophic lateral sclerosis (ALS) is the most common adult human motoneuron disease, but the vast majority of sporadic and familial cases of ALS are still of unknown origin (4). Murine models of motoneuron diseases, derived from...
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