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Article

Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis.

Brain research - 22 Jun 2006

Leichsenring Anna, Linnartz Bettina, Zhu Xin-Ran, Lübbert Hermann, Stichel Christine C

Abstract excerpt

Transgenic mice expressing a mutated human Cu/Zn superoxide dismutase (SOD1) gene develop a motor neuron disease similar to familial amyotrophic lateral sclerosis (FALS). While the histopathology and the inflammatory reactions in the spinal cord of these mice are well described, their spatiotemporal extension into brain areas and the relationship between degenerative and inflammatory events remain obscure. In the...

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Source

Identifiers

PMID: 16737688
DOI: 10.1016/j.brainres.2006.04.029

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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