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Article

Vulnerability of SRSF2-mutated chronic myelomonocytic leukemia to perturbation of the cGAS-STING pathway.

Blood advances - 10 Feb 2026

Chen Yanan, Chan Koon Chuen, Sin Chun Fung, Zheng Lichuan, Wang Dandan, Tu Lingge, He Fangfang, Hui Wan Hei Jeffrey, Leung Hoi Ki, Chan Leslie Kar Fai, Tsui Sze Pui, Chan Hoi Yi, Ma Alvin Chun Hang, Leung Anskar Y H, Sun Xuan

Abstract excerpt

ABSTRACT: Chronic myelomonocytic leukemia (CMML) is characterized by monocytosis in blood and bone marrow and natural progression to acute myeloid leukemia (AML) in ≤30% of patients. The mutation landscape of CMML has been reported, and animal models that recapitulate its clinicopathologic features and progression are needed. We report a CMML zebrafish model based on transgenic SRSF2P95H expression that closely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41346291
DOI: 10.1182/bloodadvances.2025017005
PMCID: PMC12874312

Genes

SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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