Article

The cGAS-STING pathway affects vertebral bone but does not promote intervertebral disc cell senescence or degeneration

2022-03-18

Abstract excerpt

The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral and bacterial DNA as well as self-DNA. Studies of the intervertebral disc in humans and mice demonstrate associations between aging, increased cell senescence, and disc degeneration. Herein we assessed the role of STING in SASP promotion in STING ga...

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Identifiers and source

Literature Corpus work: 01698915-e4f1-52ee-b1c3-46aff242ab49
DOI: 10.1101/2022.03.17.484614

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