Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

7 Oct 2022

Abstract excerpt

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I interferon-driven inflammatory diseases. In these pathophysiological conditions, activation of the DNA sensor cGAS and IFN production are linked to spontaneous DNA damage. Physiological, or tonic, IFN signaling on the other hand is essential to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Inflammasome and immune disorders
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36346347
DOI: 10.1084/jem.20220829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent mannerPMID 36346347Read ↗

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNASemantic proximity Read ↗

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1Semantic proximity Read ↗

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseasesSemantic proximity Read ↗

Aicardi-Goutières Syndrome caused by SAMHD1 mutation: Pathogenesis and Beyond.Semantic proximity Read ↗

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory ResponseSemantic proximity Read ↗

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read ↗

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral ResponseSemantic proximity Read ↗

STING promotes homeostatic maintenance of tissues and confers longevity with agingSemantic proximity Read ↗

Function and regulation of cGAS-STING signaling in infectious diseasesSemantic proximity Read ↗

SAMHD1 Functions and Human Diseases.Semantic proximity Read ↗

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).Semantic proximity Read ↗

Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and LupusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.