Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING Pathway

8 Jan 2021

Abstract excerpt

Pattern recognition receptors (PRRs) are germline-encoded host sensors of the innate immune system. Some human cancer cells have been reported to express PRRs. However, nucleic acid sensors in human cancers have not been studied in detail. Therefore, we systematically analyzed the expression, molecular cascade, and functions of TLR3, RIG-I, MDA5, LGP2, cGAS, and STING in human cancer cells. TLR3, TRIF, RIG-I,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33490069
DOI: 10.3389/fcell.2020.606001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING PathwayPMID 33490069Read ↗

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer ImmunotherapiesSemantic proximity Read ↗

STING Mediates Cytosolic Dna-Induced Muc5ac Mrna Expression in Human Bronchial Epithelial CellsSemantic proximity Read ↗

cGAS and STING: At the intersection of DNA and RNA virus-sensing networksSemantic proximity Read ↗

A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse FunctionsSemantic proximity Read ↗

Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and ImmunotherapySemantic proximity Read ↗

RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNASemantic proximity Read ↗

The regulation of cGAS-STING signaling by RNA virus-derived componentsSemantic proximity Read ↗

Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathwaySemantic proximity Read ↗

The Interplay between Viruses and Host DNA SensorsSemantic proximity Read ↗

The cGAS-STING Pathway: A Promising Immunotherapy TargetSemantic proximity Read ↗

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read ↗

Mesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.