Article

Zebrafish knockout of frk gene shows social impairments relevant to autism and delays brain development by increasing cell proliferation

2024-01-05

Abstract excerpt

<title>Abstract</title> <p>Fyn-related kinase (FRK) belonging to the Src family of non-receptor protein tyrosine kinases functions during the cell cycle. Here, we reported an autism spectrum disorders (ASD) patient with intragenic mutation of <italic>FRK</italic> with two other ASD risk genes. Circumventing the barrier of murine model studies, we generated the CRISPR/Cas9-engineered <italic>frk</italic><sup>−/−</...

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Literature Corpus work: acaa441b-e1fd-5c70-b229-ac274dda0762
DOI: 10.21203/rs.3.rs-3689329/v1

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