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Article

Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism.

Molecular autism - 1 Jan 2017

Kim Oc-Hee, Cho Hyun-Ju, Han Enna, Hong Ted Inpyo, Ariyasiri Krishan, Choi Jung-Hwa, Hwang Kyu-Seok, Jeong Yun-Mi, Yang Se-Yeol, Yu Kweon, Park Doo-Sang, Oh Hyun-Woo, Davis Erica E, Schwartz Charles E, Lee Jeong-Soo, Kim Hyung-Goo, Kim Cheol-Hee

Abstract excerpt

BACKGROUND: DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this kinase-encoding gene have been reported to cause microcephaly associated with either intellectual disability or autism in humans. Intellectual disability accompanied by microcephaly was recapitulated in a murine model by overexpressing Dyrk1a which mimicked Down syndrome phenotypes. However, given embryonic lethality in...

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Source

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Identifiers

PMID: 29021890
DOI: 10.1186/s13229-017-0168-2
PMCID: PMC5622473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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