Article
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.
Pediatric blood & cancer - 1 Nov 2017
Sredni Simone Treiger, Suzuki Mario, Yang Jian-Ping, Topczewski Jacek, Bailey Anders W, Gokirmak Tufan, Gross Jeffrey N, de Andrade Alexandre, Kondo Akihide, Piper David R, Tomita Tadanori
Abstract excerpt
PURPOSE: Malignant rhabdoid tumors (MRTs) are deadly embryonal tumors of the infancy. With poor survival and modest response to available therapies, more effective and less toxic treatments are needed. We hypothesized that a systematic screening of the kinome will reveal kinases that drive rhabdoid tumors and can be targeted by specific inhibitors. METHODS: We individually mutated 160 kinases in a...
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