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New insights into the roles for DYRK family in mammalian development and congenital diseases

6 Jan 2022

Abstract excerpt

The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation, apoptosis, survival, and differentiation by modifying the protein activation state, cellular localization, and turnover. In contrast to several studies in cellular models, the available evidence regarding the in vivo roles of DYRKs in mammalian development is...

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PMID: 37396550
DOI: 10.1016/j.gendis.2021.12.004

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