Article

Sex-Specific Polygenic Risk Scores for Cardiovascular Disease: A Multi-Ethnic Analysis Using the 1000 Genomes Project

2026-06-28

Abstract excerpt

<title>Abstract</title> <p>Background Polygenic risk scores (PRS) for cardiovascular disease (CVD) show poor clinical agreement, with approximately 20% of individuals simultaneously classified as both high-risk and low-risk depending on the method used. Current PRS methods fail to account for sex-specific genetic architecture despite well-documented sex differences in CVD incidence and outcomes. Methods Sex-str...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5cbe380-6b60-5994-8923-05849ca89b3d
DOI: 10.21203/rs.3.rs-10045788/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex-Specific Polygenic Risk Scores for Cardiovascular Disease: A Multi-Ethnic Analysis Using the 1000 Genomes ProjectDOI 10.21203/rs.3.rs-10045788/v1Read

Widespread and Biologically Driven Sex Disparities in Polygenic Risk Prediction Across Complex TraitsSemantic proximity Read

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read

Polygenic risk score portability for common diseases across genetically diverse populationsSemantic proximity Read

Polygenic risk score portability for common diseases across genetically diverse populations.Semantic proximity Read

Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African AmericansSemantic proximity Read

Validity of European-centric derived cardiometabolic polygenic risk scores in multi-ancestry populationsSemantic proximity Read

The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.Semantic proximity Read

Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular EventsSemantic proximity Read

Sex-stratified polygenic risk scores for coronary artery disease incidence: Insights from a 20-year cohort study.Semantic proximity Read

A sex-specific genome-wide association study of blood lipid levels in All of UsSemantic proximity Read

Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review.Semantic proximity Read

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive CardiologySemantic proximity Read