Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease.

Journal of the American College of Cardiology - 8 Sept 2026

Mazidi Mohsen, Wright Neil, Pozarickij Alfred, Millwood Iona Y, Walters Robin, Kartsonaki Christiana, Bennett Derrick A, Yao Pang, Du Huaidong, Fry Hannah, Yu Canqing, Iona Andri, Wang Baihan, Chen Yiping, Sun Dianjianyi, Yang Ling, Lv Jun, Im Pek Kei, Avery Daniel, Goel Anuj, Watkins Hugh, Wang Hao, Kyriakou Theodosios, Brennan Paul, Peto Richard, Collins Rory, Li Liming, Clarke Robert, Chen Zhengming

Abstract excerpt

BACKGROUND: Most drugs target proteins, and proteome-wide genetic analyses in diverse populations could discover potential novel and repurposed targets for improved prevention and treatment of ischemic heart disease (IHD) beyond statin therapy. OBJECTIVES: The purposes of this study were to use cis-acting single nucleotide polymorphisms (cis-pQTLs) identified for plasma proteins in East Asians and Europeans to...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

China

European People

Genome-Wide Association Study

Mendelian Randomization Analysis

Myocardial Ischemia

Polymorphism, Single Nucleotide

Prospective Studies

Proteogenomics

White People

East Asian People

Source

Identifiers

PMID: 42524807
DOI: 10.1016/j.jacc.2026.05.049

Genes

CKB
APOA5
APOE
LPA
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease.PMID 42524807Read ↗

A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestriesSemantic proximity Read ↗

Genomic atlas of 7,000 plasma proteins and their associations with diseases and traits in East Asian populationsSemantic proximity Read ↗

Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity Read ↗

Genetic associations of circulating plasma proteins with cardiometabolic diseases.Semantic proximity Read ↗

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity Read ↗

Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced predictionSemantic proximity Read ↗

Ancestry diversity in the genetic determinants of the human plasma proteome enhances identification of potential drug targetsSemantic proximity Read ↗

Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome‐Wide Mendelian Randomization and Colocalization AnalysisSemantic proximity Read ↗

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read ↗

Risk prediction of ischemic heart disease using plasma proteomics, conventional risk factors and polygenic scores in Chinese and European adultsSemantic proximity Read ↗

Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarctionSemantic proximity Read ↗

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.