Article

Ketone body driven lipid remodeling supports thermogenic adaptation to fasting

2025-06-17

Abstract excerpt

Metabolic adaptation to fasting may have conferred survival advantage to early humans and predicts weight gain caused by overnutrition in modern societies. Fasting suppresses brown adipose tissue (BAT) thermogenesis; however, it is unclear how BAT rewires cellular metabolism to balance between energy conservation and heat generation. Here, we report that BAT in mice under fasting and cold challenge consumed ketone...

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Literature Corpus work: ac6f1aea-6668-50ab-b5a8-d2618f663f78
DOI: 10.1101/2025.06.13.659540

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