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Article

Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.

Nature metabolism - 1 Dec 2022

Patrick McKenzie, Gu Zhimin, Zhang Gen, Wynn R Max, Kaphle Pranita, Cao Hui, Vu Hieu, Cai Feng, Gao Xiaofei, Zhang Yuannyu, Chen Mingyi, Ni Min, Chuang David T, DeBerardinis Ralph J, Xu Jian

Abstract excerpt

The branched-chain aminotransferase isozymes BCAT1 and BCAT2, segregated into distinct subcellular compartments and tissues, initiate the catabolism of branched-chain amino acids (BCAAs). However, whether and how BCAT isozymes cooperate with downstream enzymes to control BCAA homeostasis in an intact organism remains largely unknown. Here, we analyse system-wide metabolomic changes in BCAT1- and BCAT2-deficient...

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Share to Amino Acids, Branched-Chain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36443523
DOI: 10.1038/s42255-022-00689-4
PMCID: PMC11977170

Genes

BCAT2
BCAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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