Article
Diploid hepatocytes drive physiological liver renewal in adult humans
2020-08-07
Abstract excerpt
<h4>Summary</h4> Physiological liver cell replacement is central to maintaining the organ’s high metabolic activity, although its characteristics are difficult to study in humans. Using retrospective 14 C birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, maintaining the liver a young organ (average age < 3 years). Hepatocyte renewal is highly dependent on the ploidy l...
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Identifiers and source
- Literature Corpus work
- ac3ccaad-e747-518f-bf28-7c623666edee
- DOI
- 10.1101/2020.08.07.230086