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The Significance of Polyploid Hepatocytes During Aging Process

24 Dec 2020

Abstract excerpt

The mammalian liver contains numerous polyploid hepatocytes, and polyploidization is significantly enhanced during aging.1 In some tissues, such as bone marrow, diploid stem cells constitutively proliferate for tissue renewal and regeneration, whereas polyploidization leads to cell cycle arrest and differentiation enhancing cellular functions.2 In contrast, notably, polyploid hepatocytes are an important source...

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PMID: 33359651
DOI: 10.1016/j.jcmgh.2020.12.011

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