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Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury

14 Dec 2020

Abstract excerpt

Hepatocytes are the primary functional cells of the liver that perform essential roles in homeostasis, regeneration, and injury. Most mammalian somatic cells are diploid and contain pairs of each chromosome, but there are also polyploid cells containing additional sets of chromosomes. Hepatocytes are among the best described polyploid cells, with polyploids comprising more than 25 and 90% of the hepatocyte...

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PMID: 33764484
DOI: 10.1055/s-0040-1719175

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