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Article

Reversal of Hepatocyte Senescence After Continuous In Vivo Cell Proliferation

7 Apr 2014

Abstract excerpt

UNLABELLED: A better understanding of hepatocyte senescence could be used to treat age-dependent disease processes of the liver. Whether continuously proliferating hepatocytes could avoid or reverse senescence has not yet been fully elucidated. We confirmed that the livers of aged mice accumulated senescent and polyploid hepatocytes, which is associated with accumulation of DNA damage and activation of p53-p21...

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PMID: 24711261
DOI: 10.1002/hep.27094

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