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The Ploidy State as a Determinant of Hepatocyte Proliferation

1 Nov 2023

Abstract excerpt

The liver's unique chromosomal variations, including polyploidy and aneuploidy, influence hepatocyte identity and function. Among the most well-studied mammalian polyploid cells, hepatocytes exhibit a dynamic interplay between diploid and polyploid states. The ploidy state is dynamic as hepatocytes move through the "ploidy conveyor," undergoing ploidy reversal and re-polyploidization during proliferation. Both...

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PMID: 37967885
DOI: 10.1055/a-2211-2144

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