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Diploid hepatocytes drive physiological liver renewal in adult humans

31 May 2022

Abstract excerpt

C) birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, allowing the liver to remain a young organ (average age <3 years). Hepatocyte renewal is highly dependent on the ploidy level. Diploid hepatocytes show more than 7-fold higher annual birth rates than polyploid hepatocytes. These observations support the view that physiological liver cell renewal in humans is mainly...

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PMID: 35649419
DOI: 10.1016/j.cels.2022.05.001

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