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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

19 Dec 2014

Abstract excerpt

Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or function in vitro. We have shown previously that single mouse Lgr5+ liver stem cells can be expanded as epithelial organoids in vitro and can be differentiated into functional hepatocytes in vitro and in vivo. We now describe conditions allowing long-term...

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PMID: 25533785
DOI: 10.1016/j.cell.2014.11.050

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