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Article

Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology

1 Jan 2012

Abstract excerpt

Most cells in mammalian tissues usually contain a diploid complement of chromosomes. However, numerous studies have demonstrated a major role of "diploid-polyploid conversion" during physiopathological processes in several tissues. In the liver parenchyma, progressive polyploidization of hepatocytes takes place during postnatal growth. Indeed, at the suckling-weaning transition, cytokinesis failure events induce...

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PMID: 23150829
DOI: 10.1155/2012/282430

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