Article
Interpreting cancer genetics through a two-step "evolutionary cascade hypothesis": bridging neutral and selective perspectives.
Journal of translational medicine - 13 Feb 2026
Ottaiano Alessandro, Santorsola Mariachiara, Sabbatino Francesco, Sirica Roberto, Caraglia Francesco, Ceccarelli Anna, Granata Vincenza, Simeone Ines, Zappavigna Silvia, Berretta Massimiliano, Savarese Giovanni, Caraglia Michele
Abstract excerpt
BACKGROUND: DNA mutations are the fundamental engines of cancer, driving its initiation and progression. The forces that fuel malignancy are also the architects of evolution, shaping life through genetic variations. Mutations, in fact, can emerge naturally from endogenous processes, such as oxidative DNA damage or errors in replication, as well as induced by external factors, including cosmic radiation and...
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