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Article

Mutation-selection balance and compensatory mechanisms in tumour evolution.

Nature reviews. Genetics - 1 Apr 2021

Persi Erez, Wolf Yuri I, Horn David, Ruppin Eytan, Demichelis Francesca, Gatenby Robert A, Gillies Robert J, Koonin Eugene V

Abstract excerpt

Intratumour heterogeneity and phenotypic plasticity, sustained by a range of somatic aberrations, as well as epigenetic and metabolic adaptations, are the principal mechanisms that enable cancers to resist treatment and survive under environmental stress. A comprehensive picture of the interplay between different somatic aberrations, from point mutations to whole-genome duplications, in tumour initiation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33257848
DOI: 10.1038/s41576-020-00299-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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