Article

Recurrent triple-negative breast cancer from cysteine deprivation loses tumorigenicity via downregulation of the CST4 signaling

2022-08-16

Abstract excerpt

<title>Abstract</title> <p>Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high risk of recurrence following therapeutic treatments. Targeted cysteine therapy via inhibition of cysteine uptake by erastin effectively induces mesenchymal TNBC cells to ferroptosis. However, a small residual population of cancer cells exhibited the erastin-resistance and survived after the erastin t...

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Literature Corpus work: ac248a91-07f6-5002-b686-01ef87410aea
DOI: 10.21203/rs.3.rs-1943456/v1

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