Article

CtBP Promoted P4HB Mediates SLC7A11 Maturation to Confer Ferroptosis Resistance in Triple-Negative Breast Cancer

2025-12-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Triple-negative breast cancer (TNBC) is characterized by aggressive clinical behaviour and frequent resistance to chemotherapy. While ferroptosis—an iron-dependent form of cell death driven by lipid peroxidation—holds promise as a therapeutic strategy, its efficacy is often limited by adaptive resistance mechanisms that remain incompletely understood. C-termin...

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Literature Corpus work: fc2cac07-785c-5886-9c43-bc25deeb5adf
DOI: 10.21203/rs.3.rs-8199205/v1

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