Article

GPX4-VIM equates a proliferating DTP state in TNBC subtypes with converged vulnerabilities to autophagy and glutathione inhibition

2023-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Frequent metastatic relapses in Triple-Negative Breast Cancer (TNBC) patients with residual disease is a clinical challenge, largely due to tumor heterogeneity and absence of strategies that target proliferating chemo-tolerant cells. Here, we longitudinally modeled cellular state transitions from dormant drug-tolerant persister (DTP) into proliferating drug-tolerant persister (PDTP) in cells rep...

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Literature Corpus work: 96cce478-944b-5746-919a-6a8e612252dd
DOI: 10.1101/2023.05.18.541287

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