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Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer

29 Jan 2024

Abstract excerpt

Cancer stem cells (CSCs) are the most intractable subpopulation of triple-negative breast cancer (TNBC) cells, which have been associated with a high risk of relapse and poor prognosis. However, eradication of CSCs continues to be difficult. Here, we integrate the multiomics data of a TNBC cohort (n = 360) to identify vital markers of CSCs. We discover that EMSY, inducing a BRCAness phenotype, is preferentially...

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PMID: 38290515
DOI: 10.1016/j.xcrm.2024.101396

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