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NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells

10 Apr 2024

Abstract excerpt

Triple-negative breast cancer (TNBC) is a very aggressive and heterogeneous group of tumors. In order to develop effective therapeutic strategies, it is therefore essential to identify the subtype-specific molecular mechanisms underlying disease progression and resistance to chemotherapy. TNBC cells are highly dependent on exogenous cystine, provided by overexpression of the cystine/glutamate antiporter...

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PMID: 38600165
DOI: 10.1038/s41388-024-03025-0

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