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Chemoradiotherapy-induced ACKR2+ tumor cells drive CD8+ T cell senescence and cervical cancer recurrence

1 May 2024

Abstract excerpt

Tumor recurrence after chemoradiotherapy is challenging to overcome, and approaches to predict the recurrence remain elusive. Here, human cervical cancer tissues before and after concurrent chemoradiotherapy (CCRT) analyzed by single-cell RNA sequencing reveal that CCRT specifically promotes CD8 + T cell senescence, driven by atypical chemokine receptor 2 (ACKR2) + CCRT-resistant tumor cells. Mechanistically,...

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PMID: 38723624
DOI: 10.1016/j.xcrm.2024.101550

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