Article
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015
Lu Haiquan, Samanta Debangshu, Xiang Lisha, Zhang Huimin, Hu Hongxia, Chen Ivan, Bullen John W, Semenza Gregg L
Abstract excerpt
Triple negative breast cancer (TNBC) accounts for 10-15% of all breast cancer but is responsible for a disproportionate share of morbidity and mortality because of its aggressive characteristics and lack of targeted therapies. Chemotherapy induces enrichment of breast cancer stem cells (BCSCs), which are responsible for tumor recurrence and metastasis. Here, we demonstrate that chemotherapy induces the expression...
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