Article

Recurrent Breast Cancer Cells Depend on <i>De novo</i> Pyrimidine Biosynthesis to Suppress Ferroptosis

2025-11-17

Abstract excerpt

Breast cancer recurrence remains a major clinical challenge, often associated with therapy resistance and altered metabolic states. To define metabolic vulnerabilities of recurrent disease, we performed a CRISPR knockout screen targeting 421 metabolic genes in paired primary and recurrent HER2-driven breast cancer cell lines. While both primary and recurrent tumors shared dependencies on core metabolic pathways, r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 271eaa0b-a55c-53d8-8036-60f8531cb940
DOI: 10.1101/2025.11.17.688927

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recurrent Breast Cancer Cells Depend on <i>De novo</i> Pyrimidine Biosynthesis to Suppress FerroptosisDOI 10.1101/2025.11.17.688927Read

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis SensitivitySemantic proximity Read

Adenosine triphosphate citrate lyase alters cellular myelocytomatosis oncogene signaling and fatty acid oxidation in residual breast cancer tumor tissues after neoadjuvant treatmentSemantic proximity Read

Recurrent triple-negative breast cancer from cysteine deprivation loses tumorigenicity via downregulation of the CST4 signalingSemantic proximity Read

Targeting ferroptosis resistance resensitizes metastatic HR + HER2 − breast cancer cells to palbociclib‐hormone therapySemantic proximity Read

Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer.Semantic proximity Read

Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell CarcinomaSemantic proximity Read

Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast CancerSemantic proximity Read

Metabolic Switch in Endocrine Resistant Estrogen Receptor Positive Breast CancerSemantic proximity Read

Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistanceSemantic proximity Read

Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancersSemantic proximity Read

Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylationSemantic proximity Read

Targeting Riboflavin Kinase Induces Ferroptosis and Apoptosis in Triple-Negative Breast CancerSemantic proximity Read