Article

Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila

2025-01-06

Abstract excerpt

Aging is characterized by extensive metabolic dysregulation. Redox coenzyme nicotinamide adenine dinucleotide (NAD) can exist in oxidized (NAD+) or reduced (NADH) states, which together form a key NADH/NAD+ redox pair. Total levels of NAD decline with age in a tissue-specific manner, thereby playing a significant role in the aging process. Supplementation with NAD precursors boosts total cellular NAD levels and pr...

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Literature Corpus work: 7e935839-e578-59e6-8306-4e700ef15730
DOI: 10.1101/2025.01.06.631511

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