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Article

Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.

Cell death & disease - 25 Jun 2021

Yu Yizhou, Fedele Giorgio, Celardo Ivana, Loh Samantha H Y, Martins L Miguel

Abstract excerpt

Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial impairment. The coenzyme nicotinamide adenine dinucleotide (NAD+) is essential for both mitochondrial bioenergetics and nuclear DNA repair through NAD+-consuming poly (ADP-ribose) polymerases...

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Source

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Identifiers

PMID: 34172715
DOI: 10.1038/s41419-021-03926-y
PMCID: PMC8233423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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