TumorFusions: an integrative resource for reporting cancer-associated transcript fusions in 33 tumor types

Abstract excerpt

Fusion genes, particularly those involving kinases, have been demonstrated as drivers and are frequent therapeutic targets in cancer 1 . Here, we describe our results on detecting transcript fusions across 33 cancer types from The Cancer Genome Atlas (TCGA), totaling 9,966 cancer samples and 648 normal samples 2 . Preprocessing, including read alignment to both genome and transcriptome, and fusion detection were...

Topics

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• Databases, Genetic
• DNA Copy Number Variations
• Gene Expression Regulation, Neoplastic
• Gene Fusion
• Oncogene Proteins, Fusion
• Reproducibility of Results
• User-Computer Interface
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

ac224fbe-00ad-5089-b607-3bc3fc64a34d

DOI

10.1101/162180