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Article

Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration.

PloS one - 1 Jan 2025

Suzuki Shinsuke, Akahane Toshiaki, Tanimoto Akihide, Higashi Michiyo, Kitazono Ikumi, Kirishima Mari, Nishigaki Masakazu, Ikeda Toshiro, Kanemitsu Shuichi, Nakazawa Junichi, Akahane Erina, Nishihara Hiroshi, Uozumi Kimiharu, Yoshimitsu Makoto, Ishitsuka Kenji, Ueno Shin-Ichi

Abstract excerpt

Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly targeted therapeutics varies depending on the specific alteration, with great success reported for such therapeutics in the treatment of cancer with kinase fusion proteins. However, the involvement of actionable alterations in...

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Topics

Humans
Neoplasms
DNA Copy Number Variations
Mutation
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Oncogene Proteins, Fusion

Aged

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 39847581
DOI: 10.1371/journal.pone.0305025
PMCID: PMC11756797

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