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Oncogenic gene fusions in cancer: from biology to therapy

13 Apr 2025

Abstract excerpt

Oncogenic gene fusions occur across a broad range of cancers and are a defining feature of some cancer types. Cancers driven by gene fusion products tend to respond well to targeted therapies, where available; thus, detection of potentially targetable oncogenic fusions is necessary to select optimal treatment. Detection methods include non-sequencing methods, such as fluorescence in situ hybridization and...

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PMID: 40223139
DOI: 10.1038/s41392-025-02161-7

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