Article

Improved detection of gene fusions by applying statistical methods reveals new oncogenic RNA cancer drivers

2019-06-03

Abstract excerpt

<h4>Short Abstract</h4> The extent to which gene fusions function as drivers of cancer remains a critical open question. Current algorithms do not sufficiently identify false-positive fusions arising during library preparation, sequencing, and alignment. Here, we introduce a new algorithm, DEEPEST, that uses statistical modeling to minimize false-positives while increasing the sensitivity of fusion detection. In...

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Literature Corpus work: 4b506e2e-04a6-5361-aac9-08b179e1d3e6
DOI: 10.1101/659078

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