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Article

DG-Affinity: predicting antigen–antibody affinity with language models from sequences

13 Nov 2023

Abstract excerpt

BACKGROUND: Antibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the progress of antibody-derived drugs, showing promising efficacy in cancer and autoimmune disease therapy. A critical step of this development process is obtaining the affinity between antibodies and their binding antigens. RESULTS: In this study, we introduce a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37957563
DOI: 10.1186/s12859-023-05562-z

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