Article

Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation

2025-10-12

Abstract excerpt

<h4>SUMMARY</h4> Extracellular signals and cell-fate trajectories during vein development remain elusive, despite trailblazing insights into artery development. Here we exploit human pluripotent stem cell differentiation and mouse embryology to present a model that answers longstanding questions: vein endothelial cell (EC) differentiation unfolds in two steps driven by opposing extracellular signals. First, VEGF...

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Identifiers and source

Literature Corpus work: ac062ffa-009e-5ba7-aea2-8e232d053557
DOI: 10.1101/2025.10.11.681838

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