Article

Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of Differentiation

2020-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Haematopoietic stem cells (HSC) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endothelial cells which undergo endothelial-to-haematopoietic transition (EHT). Despite the progress achieved in recent years, the molecular mechanisms driving EHT are still poorly understood, especially in human where the AGM region is not easi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6508e9a-731f-561d-bc82-9e348d64a0e6
DOI: 10.1101/2020.04.03.023762

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of DifferentiationDOI 10.1101/2020.04.03.023762Read

Role of the cell cycle during human endothelial-to-haematopoietic transitionSemantic proximity Read

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic TransitionSemantic proximity Read

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.Semantic proximity Read

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endotheliumSemantic proximity Read

CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in humanSemantic proximity Read

Single-cell tracing of the first hematopoietic stem cell generation in human embryosSemantic proximity Read

Human vein-to-artery endothelial cell fate transition is driven by VEGF/ERK activation and PI3K inhibitionSemantic proximity Read

The genesis of human hematopoietic stem cellsSemantic proximity Read

Multimodal analysis of <i>in vitro</i> hematopoiesis reveals blood cell-specific genetic impacts on complex disease traitsSemantic proximity Read

A Highly Efficient Aorta-Gonad-Mesonephros-Like Definitive Hemogenic Endothelium From Human Pluripotent Stem CellsSemantic proximity Read

Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generationSemantic proximity Read

Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cellsSemantic proximity Read