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Article

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

23 Aug 2012

Abstract excerpt

A precise molecular identification of transmitted hepatitis C virus (HCV) genomes could illuminate key aspects of transmission biology, immunopathogenesis and natural history. We used single genome sequencing of 2,922 half or quarter genomes from plasma viral RNA to identify transmitted/founder (T/F) viruses in 17 subjects with acute community-acquired HCV infection. Sequences from 13 of 17 acute subjects, but...

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PMID: 22927816
DOI: 10.1371/journal.ppat.1002880

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