Article
Mechanisms and Consequences of Genetic Variation in Hepatitis C Virus (HCV).
Current topics in microbiology and immunology - 1 Jan 2023
Galli Andrea, Bukh Jens
Abstract excerpt
Chronic infection with hepatitis C virus (HCV) is an important contributor to the global incidence of liver diseases, including liver cirrhosis and hepatocellular carcinoma. Although common for single-stranded RNA viruses, HCV displays a remarkable high level of genetic diversity, produced primarily by the error-prone viral polymerase and host immune pressure. The high genetic heterogeneity of HCV has led to the...
Topics
- Humans
- Hepacivirus
- Hepatitis C
- Hepatitis C, Chronic
- Mutation
- Antiviral Agents
- Vaccines
- Genetic Variation