Article

Sox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness

2023-05-03

Abstract excerpt

<h4>Rationale</h4> Vascular calcification and increased extracellular matrix (ECM) stiffness are hallmarks of vascular ageing. Sox9 (SRY-Box Transcription Factor 9) is a master regulator of chondrogenesis, also expressed in the vasculature, that has been implicated in vascular smooth muscle cell (VSMC) osteo-chondrogenic conversion. <h4>Objective</h4> Here, we investigated the relationship between vascular agein...

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Literature Corpus work: abf3ef68-feea-5421-9dae-26d89a5073f5
DOI: 10.1101/2023.05.03.539285

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