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Article

ECM Modifications Driven by Age and Metabolic Stress Directly Promote Vascular Smooth Muscle Cell Osteogenic Processes.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2025

Whitehead Meredith, Faleeva Maria, Oexner Rafael, Cox Susan, Schmidt Lukas, Mayr Manuel, Shanahan Catherine M

Abstract excerpt

BACKGROUND: The ECM (extracellular matrix) provides the microenvironmental niche sensed by resident vascular smooth muscle cells (VSMCs). Aging and disease are associated with dramatic changes in ECM composition and properties; however, their impact on VSMC phenotype remains poorly studied. METHODS: Here, we describe a novel in vitro model system that utilizes endogenous ECM to study how modifications associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39817328
DOI: 10.1161/ATVBAHA.124.321467
PMCID: PMC11856005

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