Article

Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during atherosclerosis

2023-08-14

Abstract excerpt

<title>Abstract</title> Studying cardiovascular senescence is crucial for understanding disease-related changes in the cardiovascular system and their impact on health and disease. To systematically investigate the heterogeneity of senescent vascular cells in atherosclerosis, we employed the senescence reporter mouse <italic>p16tdTomato</italic><italic>+/-</italic>, overexpressed PCSK9 and fed a hig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4f95d70-dcc0-56d4-840b-249c8abfc822
DOI: 10.21203/rs.3.rs-3235572/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during atherosclerosisDOI 10.21203/rs.3.rs-3235572/v1Read

Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosisSemantic proximity Read

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across TissuesSemantic proximity Read

Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12Semantic proximity Read

Decoding and Targeting Coordinated CDKN1A and CDKN2A Senescence Programs in ECM-Dominant Cardiovascular PathologiesSemantic proximity Read

Oxidative Stress Induced Senescence Gives Rise to Transcriptionally Distinct Physiological StatesSemantic proximity Read

SenePy : Unveiling the Cell-Type Specific Landscape of Cellular Senescence through Single-Cell Analysis in Living OrganismsSemantic proximity Read

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissuesSemantic proximity Read

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Protective Effects of Fenofibrate in Acute Type A Aortic DissectionSemantic proximity Read

Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePySemantic proximity Read

Single‐Cell RNA ‐Seq Reveals Injuries in Aortic Dissection and Identifies PDGF Signalling Pathway as a Potential Therapeutic TargetSemantic proximity Read

Identification of cellular heterogeneity and key signaling pathways associated with vascular remodeling and calcification in young and old primate aortas based on single-cell analysisSemantic proximity Read