Article

An ncBAF-ETS2 Chromatin-Remodelling Axis Drives Vascular Smooth Muscle Cell Osteogenic Reprogramming in Vascular Calcification

2026-08-24

Abstract excerpt

<h4>Introduction: </h4> Vascular calcification is a detrimental ageing-related pathology that is markedly accelerated in metabolic disorders. It is driven by osteogenic differentiation of vascular smooth muscle cells (VSMCs), however epigenetic regulatory pathways activated early in this transition remain poorly defined. <h4>Methods:</h4> An in vitro calcification model was developed using primary human aortic VSM...

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Literature Corpus work: 33fb0ef6-7b82-5279-a8b0-a96307f2fc25
DOI: 10.64898/2026.08.21.746239

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