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Article

Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation.

Cardiovascular research - 14 Aug 2025

Kaistha Anuradha, Oc Sebnem, Garrido Abel Martin, Taylor James C K, Imaz Maria, Worssam Matthew D, Uryga Anna, Grootaert Mandy, Foote Kirsty, Finigan Alison, Figg Nichola, Jørgensen Helle F, Bennett Martin

Abstract excerpt

AIMS: Human atherosclerotic plaque cells display DNA damage that if left unrepaired can promote premature cell senescence. Vascular smooth muscle cells (VSMCs) predisposed to senescence promote atherogenesis and features of unstable plaques and increase neointima formation after injury. However, how premature VSMC senescence promotes vascular disease and its effects on VSMC phenotype are unknown. METHODS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Proteins

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Share to Plaque, Atherosclerotic

Source

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Identifiers

PMID: 40493738
DOI: 10.1093/cvr/cvaf102
PMCID: PMC12352304

Genes

CDKN2A
FMOD
ICAM1
SFRP4
TBK1
TMEM178B
TNFRSF11B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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